BIOCHEMISTRY Competency

BIOCHEMISTRY Competency 208.5.1: DNA, RNA – The graduate demonstrates how nucleic acid polymers can transform cells and transmit information within the cell. Task 1: DNA and RNA Introduction: There is much talk in the news about stem cell research. It is important for the public and policy makers to understand how basic body cells transmit information and replicate themselves in order to make informed decisions. You should compile your work for this task in a single document (e.g., Microsoft Word, Google Document) that includes diagrams, text explanations, and references. If a requirement asks for an explanation, you should provide a written response in a narrative style (i.e., complete sentences rather than bullet points). Note: Multimedia presentations (e.g., PowerPoint, Keynote) will not be accepted due to potential originality concerns. Note: Please save submission documents as *.doc, *.docx, *.rtf, or *.pdf files. If you are using Google Documents, you must save the file in *.pdf format and upload the *.pdf file. Scenario: You are a biochemistry specialist who has been asked to provide information on the role of DNA and RNA in the transmission of information within the cell. The audience for your report is a group of medical paraprofessionals at a community health center. Requirements: A. Create an original diagram, or series of diagrams, with clear labels, that demonstrates the process of DNA replication of the leading and lagging strands. Note: Including the following components can aid in demonstrating this process: DNA, replication fork, helicase, single-stranded binding proteins, 5’ and 3’ ends of DNA, primase, RNA primer, DNA polymerase, and Okazaki fragments. Additionally, providing a brief description of the functions of the enzymes can clarify their role in your diagram. B. Create an original diagram, or series of diagrams, with clear labels, that demonstrates the role of the ligase enzyme in the replication of the lagging strand. Note: Including the following components can aid in demonstrating this process: DNA, Okazaki fragments, and DNA ligase. Additionally, providing a brief description of the functions of the enzymes can clarify their role in your diagram. C. Create an original diagram, or series of diagrams, with clear labels, that demonstrates each of the following: ● the process of transcription ● the process of translation ● how mRNA connects the processes of transcription and translation Note: Including the following components can aid in demonstrating these processes: DNA, mRNA, RNA polymerase, nucleus, ribosome, tRNA, amino acids, and growing protein/polypeptide. Additionally, providing a brief description of the functions of the enzymes can clarify their role in your diagram. D. Explain the role of RNA polymerase inhibition in causing the poisonous effect of the death cap mushroom. E. When you use sources, include all in-text citations and references in APA format. Note: For definitions of terms commonly used in the rubric, see the Rubric Terms web link included in the Evaluation Procedures section. Note: When using sources to support ideas and elements in an assessment, the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment. Note: No more than a combined total of 30% of a submission can be directly quoted or closely paraphrased from sources, even if cited correctly. For tips on using APA style, please refer to the APA Handout web link included in the General Instructions section.

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