Transcription factors as biomarkers in cancer diagnosis


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Transcription factors control the cell fate choice of undifferentiated cells. Certain transcription factors are almost always expressed in tumour cells – indicating proto-oncogene function of those transcription factors (eg: c-MYC). This project will review the expression patterns of MAF family of transcription factors and their co-relation in multiple myeloma. Moreover, expression patterns in cell line will be co-related with genomic variation using Sanger centre Copy Number Variation Analysis.
Structure
Etiology of cancer1
Transcription factors 2
Transcription factors in cancer 3
Transcription factors as Biomarkers 4
Pros and Cons of Myc 5
ELISA for Myc 6
References just from articles preferable from pubmed articles



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